Title: On a Generalization of Local Independence in Item Response Theory Authors: Stefano Noventa, Andrea Spoto, Jürgen Heller, Augustin Kelava Affiliation: University of Tübingen, Germany; University of Padova, Italy Abstract: Knowledge Space Theory (KST) structures can be introduced within Item Response Theory (IRT) as a possible way to model local dependence (LD) between items. This allows to generalize the usual characterization of local independence without introducing new parameters and to merge the information provided by the IRT and KST perspectives. In detail, connections are established between the KST Simple Learning Model (SLM) and the IRT General Graded Response Model (GRM), and between the KST Basic Local Independence model (BLIM) and IRT models in general. As a consequence, IRT models become a subset of KST models and both local independence assumption and IRT likelihood functions can be generalized to account for the existence of prerequisite relations between the items. Considerations are drawn for the modeling of both dichotomous and polytomous items, and for their interpretation (e.g., relevance and meaning of the parameters, definition of polytomous items as knowledge structures of dichotomous ones, interpretation of Rasch model as a probabilistic version of Guttman's scale).