Title: Optimizing Statistical Power in Complex Study Designs in Psychology: An Application of Machine Learning Authors: Rudolf Debelak, Felix Zimmer Abstract: The planning of an empirical study in psychology always includes the planning of the sample collection. This requires the balancing of several factors: On the one hand, the data collection should be as inexpensive as possible, and on the other hand, the collected data set must be large enough to reliably detect suspected effects. Furthermore, planning the data collection may involve complex decisions, such as determining the number of groups and individuals per group in a multilevel design. These decisions, in turn, affect the cost and power of statistical tests. In this talk, we present a new method that supports finding an optimal study design using machine learning methods. Possible applications are a) finding a design with fixed power that is as inexpensive as possible, and b) finding a design with as high power as possible given a fixed cost budget. The new method is demonstrated using some scenarios from classical statistics, multilevel modeling, and item response theory. In summary, we find that the application of the new method is promising and more efficient than the evaluation of possible study designs by hand. The proposed method is implemented in the R package mlpwr.